Scientific Programme

All times are CET

WEDNESDAY OCTOBER 27 2021

14:00-14:30    Welcome and introduction

• R. de Franchis (Milan, Italy)
  
• Tribute to the Baveno Legends
  
• Tom Boyer
• Andy Burroughs
• Roberto Groszmann
• Luigi Pagliaro

14:30-15:15    INTRODUCTORY LECTURES

• Chairpersons: J. Bosch (Bern, Switzerland), R. de Franchis (Milan, Italy), G. Garcia-Tsao (New Haven, USA)
  LECTURE-1: New concept of risk stratification
  J.G. Abraldes (Edmonton, Canada)
  LECTURE-2: Clinical stages and ordinal outcomes in portal hypertension
  G. D’Amico (Palermo, Italy)
  LECTURE-3: Lifestyle and genetic modifiers of liver disease progression
  A. Berzigotti (Bern, Switzerland)
  

15.15-15.30    Break


WEDNESDAY OCTOBER 27 2021

15.30-18.30    SESSION 1

• EVALUATION AND RISK STRATIFICATION
  

15.30-16-15   Part 1: HVPG as a gold standard

• Chairpersons: J.C. Garcia-Pagàn (Barcelona), Z. Haskal (Charlotteville)
  Panelists: F. Schepis (Modena), R. Gaba (Chicago), H. Ferral (Evanston)
  • Quality Metrics in HVPG and Porto-Systemic Pressure Gradient (PPG)
  • Usefulness of HVPG in:
    • the diagnosis of CSPH in cirrhosis of different etiologies
    • assessing the response to vasoactive drugs for risk stratification of variceal (re-)bleeding
    • assessing the prognosis of patients with cirrhosis
    • clinical trials vs. proof of concept studies
  • PPG in the setting of TIPS
  • Consensus statements

16.15-16.30    Break


16.30-18.30   Part 2: Noninvasive tools for cACLD and portal hypertension

• Chairpersons: A. Berzigotti (Bern), J. Genescà (Barcelona)
  Panelists: J.G. Abraldes (Edmonton, Canada), J. Fallowfield (Edinburgh, United Kingdom), M. Thiele (Odense, Denmark)
  • cACLD and CSPH
  • Detection of varices with noninvasive tools and screening endoscopy
  • Use of noninvasive tools for prognosis in cirrhosis
  • Spleen stiffness
  • Emerging non-invasive markers: imaging, blood and liver clearance tests
  • Proposed consensus statements

End of the Day


THURSDAY OCTOBER 28 2021

14:00-14:30    Presentation of selected abstracts

14:00-17:30    Session 2

• NEW SCENARIOS
  

14.30-15.15   Part 1: Progression and regression of cirrhosis

• Chairpersons: W. Laleman (Leuven), D. Patch (London)
  LECTURE-4: PELS in progression. Can they regress?
  I. Wanless (Halifax)
  LECTURE-5: Fibrogenesis and regression of fibrosis
  M. Pinzani (London
  LECTURE-6: Angiogenesis and progression of ACLD
  V. Shah (Rochester)
  

15.15-15.30    Break

• LECTURE-7: Drugs to modify liver fibrosis progression and regression (preclinical and clinical studies
  J. Gracia (Barcelona)
  

15.45-16.30   Part 2: Impact of etiological therapies in the course of cirrhosis

• Chairpersons: M. Mandorfer (Vienna, Austria), E. Tsochatzis (London, United Kingdom)
  Panelists: S. Francque (Antwerp, Belgium), J. Jia (Bejing, China), S. Lens (Barcelona, Spain), H. Yoshiji (Kashihara, Japan
  • Impact of etiological therapies on disease progression vs. regression in
    • Alcohol-related liver disease
    • Non-alcoholic fatty liver disease
    • Hepatitis B
    • Hepatitis C
  • Presentation of recommendations for the management of cirrhosis after control of the primary etiological factor

16.30-16.45    Break

16.45-17.30   Part 3: Impact of non-etiological therapies in the course of cirrhosis

• Chairpersons: A. Albillos (Madrid), J. Trebicka (Frankfurt)
  Panelists: J. Bajaj (Richmond), J. Gracia (Barcelona), A. Krag (Odense), W. Laleman (Leuven), V. Shah (Rochester)
  
  
  • Impact of drugs acting on the gut/microbiome
  • Impact of statins and FXR/PPAR agonists in the treatment of patients with cirrhosis and portal hypertension
  • Use of anticoagulants (LMWH, DOAC) and antiplatelet drugs (ASS) in the management of cirrhosis and portal hypertension
  • Proposed consensus statements

17.30-17.45    Break

17.45-19.00    Session 3

• CLINICAL SETTINGS
  

17.45-19.00   Part 1: Preventing (first) decompensation. Review of current evidence

• Chairpersons: J. Bosch (Bern), C. Ripoll (Halle)
  Panelists: V. Calvaruso (Palermo), R. Bañares (Madrid), S. Gomes Rodrigues (Bern), A. Dell’Era (Milan), C. Villanueva (Barcelona), D. Tripathi (Birmingham)
  • Results of the questionnaire
  • Definition of decompensation:
    • Systematic review of studies that evaluate the natural history of cirrhosis and their definition of decompensation
    • The role of jaundice, perihepatic ascites, MHE and bleeding due to portal hypertensive gastropathy in the definition of decompensation
    • Impact of the sole presence of infection and of sarcopenia (without other manifestations of decompensation) in the natural history of compensated cirrhosis
  • Use of NSBB in prevention of (first) decompensation:
    • Specific evaluation of the effect of CSPH, reduction of HVPG and other predictive factors
    • Meta-analysis with individual patient data on the effects of Carvedilol in the prevention of first decompensation
  • Proposed Consensus Statements: Prevention of first decompensation

End of the Day


FRIDAY OCTOBER 29 2021

14:00-14:30    Presentation of selected abstracts

14:30-15:30   INDUSTRY SPONSORED SYMPOSIUM

15.30-15.45    Break
15.45-18.15    Session 3

• CLINICAL SETTINGS (CONTINUED)
  

15.45-16.45   Part 2: Acute variceal bleeding

• Chairpersons: D. Thabut (Paris), V. Hernández-Gea (Barcelona)
  Panelists: D. Patch (London), A. Cárdenas (Barcelona), A. Escorsell (Barcelona), M. Rudler (Paris), B. Procopet (Cluj-Napoca), X. Luo (Chengdu), G. Han (Xi’An)
  
  
  • Patient Risk stratification and prognostic factors
  • Novelties in general management of Acute Variceal Bleeding (AVB)
  • Endoscopic management: classic and new therapies
  • Pre-emptive TIPS
  • Management of refractory bleeding
  • Proposed consensus statements

16.45-17:00    Break


17.00-18.15   Part 3: Preventing further decompensation. Review of current evidence

• Chairpersons: G. Garcia-Tsao (New Haven), T. Reiberger (Vienna)
  Panelists: C. Bureau (Toulouse), G. D’Amico (Palermo), V. La Mura (Milan), S. Piano (Padua), P. Tandon (Edmonton), L. Turco (Modena)
  
  
  • Clinical concept of further decompensation: outcomes and risk stratification
    • Mortality per type of initial event (ascites, variceal hemorrhage)
    • Further decompensation per type of initial event (VH or/and ascites)
  • Prevention of further decompensation
    • Prevention of rebleeding and other further decompensating events
    • Should NSBB be used in patients with ascites for the prevention of further decompensation?
    • Readdress use of NSBB in patients with refractory ascites
    • TIPS - redefining candidates
  • Sarcopenia and frailty. Exploring its relationship with further decompensation
  • Concept of cirrhosis re-compensation

End of the Day


SATURDAY OCTOBER 30 2021

14:00-15:00   INDUSTRY SPONSORED SYMPOSIUM

15.15-16:30    Break


Session 4

• VASCULAR LIVER DISORDERS
  

15.15-16.30   Part 1: SPLANCHNIC VEIN THROMBOSIS

• Chairpersons: D. Valla (Clichy), S. Sarin (New Delhi)
  Panelists: F. Turon (Barcelona), M. Barrufet (Barcelona), J.J. Kiladjian (Paris), A. Plessier (Clichy), M. Primignani (Milan), A. Baiges (Barcelona)
  
  
  • Portal vein thrombosis. Anticoagulation vs Interventional radiology
  • Staging of portal vein thrombosis. Recurrent thrombosis and prognostic factors for recurrence
  • Myeloproliferative neoplasia and splanchnic vein thrombosis: Diagnosis and management

16.30-16.45    Break


16.45-18.00   Part 2: OTHER ISSUES IN VASCULAR LIVER DISORDERS

• Chairpersons: A. de Gottardi (Lugano), P.E. Rautou (Paris)
  Panelists: S. Murad (Rotterdam), V. Paradis (Clichy), M. Senzolo (Padua), L. Tellez (Madrid)
  
  
  • Anticoagulation (including DOACS) in cirrhotic and non-cirrhotic patients
  • Portosinusoidal vascular disease/Idiopathic portal hypertension/noncirrhotic portal hypertension: refining diagnostic criteria including histological criteria
  • Presentation of Consensus Statements (both part 1 and 2)

18.00-18.15    Break



18.15-18.45    DIGITAL BAVENO VII MEETING WRAP UP

• R. de Franchis (Milan, Italy)
• G. Garcia-Tsao (New Haven, Usa)
• J. Bosch (Bern, Switzerland)

End of the Day